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Wet & dry Milling - Application in Tablet Manufacturing

  • Categories:Solution
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  • Time of issue:2019-10-15 10:33
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(Summary description)Using Kmill for wet and dry milling can significantly reduce drying time, reduce fines and improve yield.

Wet & dry Milling - Application in Tablet Manufacturing

(Summary description)Using Kmill for wet and dry milling can significantly reduce drying time, reduce fines and improve yield.

  • Categories:Solution
  • Author:
  • Origin:
  • Time of issue:2019-10-15 10:33
  • Views:
Information
Wet Milling
In the Tablet Manufacturing Process, powders such as lactose, active ingredient, binders, etc. are mixed to form wet mass. High Shear Mixer/Granulator is used to mix and granulate this wet mass and form lumps. 
 
Large lumps need longer time to dry. Smaller lumps need less time to dry. If drying time is set for large lumps, smaller lumps will form overly dried hard small particles. If drying time is set for small lumps, the large lumps will not be dried in the center. Milling of overly dried hard small particles will result in too much fines. Milling of larger lumps with moist centers will result in smearing of the screen.
 
Hence it is necessary to use Kmill to provide similarly sized wet granules prior to drying. It can significantly reduce drying time by 25% and reduce fines by more than 20%. 
 
Dry Milling
After Fluid Bed Drying, Kmill is used for final sizing of dry product to suit the final use. In tableting, particle flowability and uniformity is critical for tablet press. Kmill can achieve a tight particle size distribution and ensure the repeatable milling result.
 
Using Kmill for wet conditioning of high shear granulated material and post fluid bed dryer milling can improve *yield by 30%. 
 
Remark: *yield  means the particle sizes on target range.
 

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